The Democratic nominee was pressed on why her policies on immigration and climate have changed since she ran for president in 2019.
Harris was under pressure to finally face questions but she shared the 27-minute, pre-recorded interview with her running mate, Minnesota Governor Tim Walz.
Her Republican opponent Donald Trump used a single-word in his review after it concluded.
The vice-president was forced to defend the White House’s economic track record, as inflation and high cost-of-living prices continue to hurt Americans.
Polls have regularly suggested that voters would prefer Trump’s handling of the economy. But the most tense exchanges centred on the evolution of her policy positions.
Harris referred to her effort to address climate change and support of the Green New Deal, a Democratic proposal to reduce reliance on fossil fuels, as something that remains a steadfast value when pressured about her shifting policy positions.
The vice-president pointed to the Biden administration’s work on the Inflation Reduction Act, which funnelled hundreds of billions of dollars to renewable energy and electric vehicle tax credit and rebate programs.
Harris did not explain her reversal on banning fracking – a technique for recovering gas and oil from shale rock used by an industry that is particularly strong in the battleground state of Pennsylvania.
Brian Fallon, a campaign spokesperson, said on social media that the Biden administration’s clean energy investments have proven the ability to make progress on climate without those past stances.
Earlier this year, the vice-president supported a hardline bipartisan border security deal that would have included hundreds of millions of dollars for border wall construction.
Trump pressured Republicans in Congress to kill the deal, but Harris has promised to sign it into law if elected. She committed to passing it again during the interview.