The Blue’s manager Enzo Maresca revealed.
The 24-year-old missed much of last season after undergoing hamstring surgery, which was designed to help him overcome a series of injuries, but he returned to action last month.
He has suffered a further half dozen injuries to his knee, thigh and ankle – as well as an absence with illness.
Maresca played down concerns about a long-term lay-off but confirmed James will miss Saturday’s match at Leicester.
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He said James unfortunately felt something small in training two days ago, adding that they do not know for how long he would be fit, but hope it will happen soon.
Maresca also said James is out for the weekend as they do not want to take a risk for the weekend.
The Manager further stated that It’s probably difficult the Blues’ Captain can be available for next Thursday’s Conference League.
The likes of Cole Palmer, Levi Colwill, Wesley Fofana, Malo Gusto and Romeo Lavia are all available despite pulling out of international duty last week.
But there is caution around Moises Caicedo and Enzo Fernandez with Maresca saying his starting team will not be at 100%, with those traveling from international duty in South America completing just one training session on Friday before the match.